“And so we age.” Central to this “deep chemistry” is the Krebs cycle, a complex series of reactions whereby almost all cells break down carbohydrates, fats, and proteins to produce energy, with carbon dioxide and hydrogen as waste products.
“Tissue function eventually becomes strained, biosynthetic pathways falter, ATP synthesis declines and the delicate web of symbiosis between tissues begins to fray,” writes the author. The vicissitudes of life unravel the delicate symbiosis between living tissues, and hypoxia, infections, inflammation, and mutations all hamper energy flow. All creatures produce energy, and all living tissues consume it the second law of thermodynamics assures that this process is imperfect. Lane, a professor of evolutionary biology and author of The Vital Question and Life Ascending, reminds us that energy flow animates cells and sets them apart from inanimate matter. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.An enthusiastic, up-to-date overview of the biochemistry of life. Life is at root a chemical phenomenon: this is its deep logic.
Enlivened by Lane's talent for distilling and humanizing complex research, Transformer offers an essential read for anyone fascinated by biology's great mysteries.
How can the same pathway create and destroy? What might our study of the Krebs cycle teach us about the mysteries of aging and the hardest problem of all, consciousness? Transformer unites the story of our planet with the story of our cells-what makes us the way we are, and how it connects us to the origin of life. Yet this same cycle, spinning in reverse, also created the chemical building blocks that enabled the emergence of life on our planet. Lane reveals the beautiful, violent world within our cells, where hydrogen atoms are stripped from the carbon skeletons of food and fed to the ravenous beast of oxygen. Transformer is Lane's voyage, as a biochemist, to find the inner meaning of the Krebs cycle-and its reverse-why it is still spinning at the heart of life and death today. Lane is among the vanguard of researchers asking why the Krebs cycle, the "perfect circle" at the heart of metabolism, remains so elusive more than eighty years after its discovery. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight -how the same simple chemistry gives rise to life and causes our demise. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. Information is important, but it is only part of what makes us alive. What brings the Earth to life, and our own lives to an end? For decades, biology has been dominated by the study of genetic information.
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